Gamma oscillations
Cho et al., Long-range inhibition synchronizes and updates prefrontal task activity, Nature, April 26, 2023.
Sohal, Transforming Discoveries About Cortical Microcircuits and Gamma Oscillations Into New Treatments for Cognitive Deficits in Schizophrenia, American Journal of Psychiatry, Apr;179(4):267-276.
Cho et al., Cross-hemispheric gamma synchrony between parvalbumin interneurons supports behavioral adaptation during rule shift learning. Nature Neuroscience, Jul;23(7):892-902.
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife. 2017 Dec 5;6.
How Close Are We to Understanding What (if Anything) γ Oscillations Do in Cortical Circuits?. J Neurosci. 2016 Oct 12;36(41):10489-10495.
Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice. Neuron. 2015 Mar 18;85(6):1332-43.
Insights into cortical oscillations arising from optogenetic studies. Biol Psychiatry. 2012 Jun 15;71(12):1039-45.
Autism - Excitatory Circuits
Frost et al., Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior. PLoS Biology, May 3, 2021.
Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. Cell Rep. 2020 Apr 14;31(2):107495
Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity. Neuron. 2018 Nov 21;100(4):831-845.
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. Mol Psychiatry. 2018 Oct;23(10):2078-2089.
DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling. Mol Psychiatry. 2018 Feb;23(2):467-475.
Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism. Biol Psychiatry. 2016 Apr 15;79(8):667-75.
Autism - Inhibitory Circuits
Cunniff et al., Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz. eLife, Nov 6;9:e54835.
Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons. Nat Commun. 2019 Nov 1;10(1):4994.
Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders. Mol Psychiatry. 2019 Sep;24(9):1248-1257.
Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition. J Neurosci. 2020 Mar 11;40(11):2215-2227.
Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons. Cereb Cortex. 2018 Nov 1;28(11):3868-3879.
The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. Cell Rep. 2015 May 12;11(6):944-956.
Anxiety and mood circuits
Jackson et al., Amygdala-hippocampus somatostatin interneuron beta-synchrony underlies a cross-species biomarker of emotional state, Neuron, Jan 23 (online).
Cunniff et al., Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz. eLife, Nov 6;9:e54835.
Lee et al., VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks. Neuron. 2019 Jun 19;102(6):1223-1234.
Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion. Neuron. 2019 Jun 5;102(5):944-959.
An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood. Cell. 2018 Nov 29;175(6):1688-1700.
Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs. Cell Rep. 2016 Dec 13;17(11):2882-2890.
Thalamo-prefrontal circuits
Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion. Neuron. 2019 Jun 5;102(5):944-959.
Roles of Prefrontal Cortex and Mediodorsal Thalamus in Task Engagement and Behavioral Flexibility. J Neurosci. 2018 Mar 7;38(10):2569-2578.
Dopamine
Dopamine D2 Receptors Modulate Pyramidal Neurons in Mouse Medial Prefrontal Cortex through a Stimulatory G-Protein Pathway. J Neurosci. 2017 Oct 18;37(42):10063-10073.
Tonic or Phasic Stimulation of Dopaminergic Projections to Prefrontal Cortex Causes Mice to Maintain or Deviate from Previously Learned Behavioral Strategies. J Neurosci. 2017 Aug 30;37(35):8315-8329.
Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex. J Neurosci. 2012 Apr 4;32(14):4959-71.
Seizures
Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures. Neuron. 2017 Jan 18;93(2):291-298.
Surprises about 'interneurons'
Malik et al., Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition, Cell, April 28.
Sohal, Transforming Discoveries About Cortical Microcircuits and Gamma Oscillations Into New Treatments for Cognitive Deficits in Schizophrenia, American Journal of Psychiatry, April.
Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons. Nat Commun. 2019 Nov 1;10(1):4994.
A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior. J Neurosci. 2014 Aug 27;34(35):11519-25.
Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Neuron. 2014 Jan 8;81(1):61-8.
Network analysis
Frost et al., Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior. PLoS Biology, May 3, 2021.
Cunniff et al., Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz. eLife, Nov 6;9:e54835.
An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood. Cell. 2018 Nov 29;175(6):1688-1700.
Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity. J Neurophysiol. 2016 May 1;115(5):2359-75.