Papers by subject

Gamma oscillations

• Cho et al., Long-range inhibition synchronizes and updates prefrontal task activity, Nature, April 26, 2023.

• Sohal, Transforming Discoveries About Cortical Microcircuits and Gamma Oscillations Into New Treatments for Cognitive Deficits in Schizophrenia, American Journal of Psychiatry, Apr;179(4):267-276.
• Cho et al., Cross-hemispheric gamma synchrony between parvalbumin interneurons supports behavioral adaptation during rule shift learning. Nature Neuroscience, Jul;23(7):892-902.
• Athilingam et al., Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife. 2017 Dec 5;6.
• Sohal, How Close Are We to Understanding What (if Anything) γ Oscillations Do in Cortical Circuits?. J Neurosci. 2016 Oct 12;36(41):10489-10495.
• Cho et al., Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice. Neuron. 2015 Mar 18;85(6):1332-43.
• Sohal, Insights into cortical oscillations arising from optogenetic studies. Biol Psychiatry. 2012 Jun 15;71(12):1039-45.

Autism - Excitatory Circuits

• Frost et al., Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior. PLoS Biology, May 3, 2021.
• Fazel Darbandi et al., Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. Cell Rep. 2020 Apr 14;31(2):107495

• Martin et al., DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling. Mol Psychiatry. 2018 Feb;23(2):467-475.
• Luongo et al., Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism. Biol Psychiatry. 2016 Apr 15;79(8):667-75.

Autism - Inhibitory Circuits

• Cunniff et al., Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz. eLife, Nov 6;9:e54835.
• Malik et al., Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons. Nat Commun. 2019 Nov 1;10(1):4994.
• Sohal and Rubenstein, Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders. Mol Psychiatry. 2019 Sep;24(9):1248-1257.
• Southwell et al., Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition. J Neurosci. 2020 Mar 11;40(11):2215-2227.

• Meda et al., Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion. Neuron. 2019 Jun 5;102(5):944-959.
• Kirkby et al., An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood. Cell. 2018 Nov 29;175(6):1688-1700.
• Kjaerby et al., Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs. Cell Rep. 2016 Dec 13;17(11):2882-2890.

Thalamo-prefrontal circuits

• Meda et al., Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion. Neuron. 2019 Jun 5;102(5):944-959.
• Marton et al., Roles of Prefrontal Cortex and Mediodorsal Thalamus in Task Engagement and Behavioral Flexibility. J Neurosci. 2018 Mar 7;38(10):2569-2578.

Dopamine

• Robinson and Sohal, Dopamine D2 Receptors Modulate Pyramidal Neurons in Mouse Medial Prefrontal Cortex through a Stimulatory G-Protein Pathway. J Neurosci. 2017 Oct 18;37(42):10063-10073.
• Ellwood, Patel and Wadia et al. Tonic or Phasic Stimulation of Dopaminergic Projections to Prefrontal Cortex Causes Mice to Maintain or Deviate from Previously Learned Behavioral Strategies. J Neurosci. 2017 Aug 30;37(35):8315-8329.
• Gee et al., Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex. J Neurosci. 2012 Apr 4;32(14):4959-71.

Seizures

• Khoshkhoo et al. Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures. Neuron. 2017 Jan 18;93(2):291-298.

Surprises about 'interneurons'

• Zhu et al., Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility external site (opens in a new window) . Neuron, May 12 (online).

• Cho et al., Long-range inhibition synchronizes and updates prefrontal task activity, Nature, April 26, 2023.

• Malik et al., Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition, Cell, April 28.

• Sohal, Transforming Discoveries About Cortical Microcircuits and Gamma Oscillations Into New Treatments for Cognitive Deficits in Schizophrenia, American Journal of Psychiatry, April.

• Malik et al., Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons. Nat Commun. 2019 Nov 1;10(1):4994.
• Lee et al., A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior. J Neurosci. 2014 Aug 27;34(35):11519-25.
• Lee, Gee et al., Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Neuron. 2014 Jan 8;81(1):61-8.

Network analysis

• Frost et al., Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior. PLoS Biology, May 3, 2021.
• Cunniff et al., Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene Pogz. eLife, Nov 6;9:e54835.
• Kirkby et al., An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood. Cell. 2018 Nov 29;175(6):1688-1700.
• Luongo et al., Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity. J Neurophysiol. 2016 May 1;115(5):2359-75.